- Associate Professor
Department of Biophysics
All India Institute of Medical Sciences, New Delhi-110029
Email : jyotirmoybanerjee1@gmail.com
About:
Dr Banerjee's pre-doctoral studies were at School of Biotechnology, Jiwaji
University, Gwalior, doctoral work at Department of Biophysics, University of Delhi South
Campus, New Delhi and post-doctoral work at University of Maryland School of Medicine,
Baltimore, USA. Dr. Banerjee joined Centre of Excellence for Epilepsy in December, 2012.
Since then he has been working on understanding the abnormal synaptic transmission
associated with epilepsy. The major emphasis of his research is directed towards identifying
aberrant epileptogenic networks and its correlation with cellular electrophysiological
findings. So far his work on resected brain samples from patients undergoing epilepsy
surgery has highlighted the importance of neurotransmitter-mediated events in genesis of
epileptiform activities. The ongoing translational research at Dr. Banerjee's lab is of immense
importance for the understanding of this distributed network disorder and creating better
paradigms for effective treatment.
The current focus of Dr. Banerjee's lab is to identify pathology specific alteration in
synaptic transmission recorded from targeted brain specimens obtained from the
epileptogenic zone of patients with drug-resistant epilepsy and its correlation with the electro-
clinical findings. This work provides new concepts about the mechanism of seizure
generation which varies among various epilepsy pathologies. He has recently shown that the
endogenous NMDA receptor activity plays a crucial role in generating hyper excitable
networks in patients with mesial temporal lobe epilepsy (MTLE). The members of his lab are
also working on analysing abnormal synaptic transmission associated with cortical dysplasia
(CD). The correlation of clinical findings with the molecular and cellular data has provided a
deep insight in to the process of epileptogenesis. Once established these observations will
help neurosurgeons across the world in accurate localization of epileptogenic zones/networks
and increase the possibility of a better seizure outcome.
:
List of Publications
Research Articles:
1. Bera A, Srivastava A, Dubey V, Dixit AB, Tripathi M, Sharma MC, Lalwani S, Chandra PS, Banerjee J*. Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE). 2022, Neurological Research; doi: 10.1080/01616412.2022.2051131 (Article in press).
2.Dubey V, Dey S, Dixit AB, Tripathi M, Chandra PS, Banerjee J. Differential glutamate receptor expression and function in the hippocampus, anterior temporal lobe and neocortex in a pilocarpine model of temporal lobe epilepsy. 2022, Experimental Neurology; 347:113916. doi: 10.1016/j.expneurol.2021.113916.. ,
3.Dey S, Banerjee Dixit A, Tripathi M, Doddamani RS, Sharma MC, Lalwani S, Chandra PS, Banerjee J. Altered hippocampal kynurenine pathway metabolism contribute to hyperexcitability in human mesial temporal lobe epilepsy-hippocampal sclerosis. 2021, British Journal of Pharmacology; 178:3959-3976. doi: 10.1111/bph.15534. ,
4. Kumar S, Shanker OR, Kumari N, Tripathi M, Chandra PS, Dixit AB, Banerjee J. Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets. 2021, Expert Opinion on Therapeutic Targets; 25:509-519. doi: 10.1080/14728222.2021.1953475.
5. Banerjee J, Srivastava A, Sharma D, Dey S, Tripathi M, Sharma MC, et al. Differential regulation of glutamatergic activity in the hippocampus and anterior temporal lobe by cyclin dependent kinase 5 (Cdk5) in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 2021, Neuroscience Letters; 761: 136096. doi: 10.1016/j.neulet.2021.136096.
6. Dey S, Doddamani R, Dixit AB, Tripathi M, Sharma MC, Chandra PS, Banerjee J. Altered spontaneous glutamatergic and GABAergic activity in the peritumoral cortex of low-grade gliomas presenting with history of seizures. 2021, Frontiers in Neuroscience; 15:689769. doi:10.3389/fnins.2021.689769
7. Sharma D, Dixit AB, Dey S, Tripathi M, Doddamani R, Sharma MC, Lalwani S, Gurjar HK, Chandra PS, Banerjee J. Increased levels of ?4-containing GABAA receptors in focal cortical dysplasia: A possible cause of benzodiazepine resistance. 2021, Neurochemistry International; 148:105084. doi: 10.1016/j.neuint.2021.105084
8. Kumar K, Yadav N, Banerjee J, Tripathi M, Sharma MC, Lalwani S, Siraj F, Chandra PS, Sengupta S, Dixit AB. Mass spectrometry-based lipidomic analysis reveals altered lipid profile in brain tissues resected from patients with focal cortical dysplasia (FCD). 2021, Epilepsy Research; 177:106773. doi: 10.1016/j.eplepsyres.2021.106773.
9. Srivastava A, Kumar K, Banerjee J, Tripathi M, Dubey V, Sharma D, Yadav N, Sharma MC, Lalwani S, Doddamani R, Chandra PS, Dixit AB. Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients. 2021, Molecular Brain; 14:120. doi: 10.1186/s13041-021-00832-4.
10. Kumar S, Attrish D, Srivastava A, Banerjee J, Tripathi M, Chandra PS et al. Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy. 2021, Expert Opin Ther Targets; 25:75-85. doi: 10.1080/14728222.2021
11. Banerjee J, Dey S, Dixit AB, Doddamani R, Sharma MC, Garg A, et al. GABAA Receptor-Mediated Epileptogenicity in Focal Cortical Dysplasia (FCD) Depends on Age at Epilepsy Onset. 2020, Front Cell Neurosci; 14:562811. doi: 10.3389/fncel.2020.562811
12. Banerjee J, Dey S, Dixit AB, Tripathi M, Doddamani R, Sharma MC, et al. ?7 nicotinic receptors contributes to glutamatergic activity in the hippocampus of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 2020, J Neural Transmission; 127:1441-1446. doi: 10.1007/s00702-020-02239-2.
13.Banerjee J, Tripathi M, Chandra PS, Dixit AB. Do SARS-CoV2 viral proteins have neuromodulatory properties? 2020, Neurol India; 68:274-275. doi: 10.4103/0028-3886.283760.
14. Srivastava A, Banerjee J, Dubey V, Tripathi M, Chandra PS, Sharma MC, Lalwani S, Siraj F, Doddamani R, Dixit AB. Role of Altered Expression, Activity and Sub-cellular Distribution of Various Histone Deacetylases (HDACs) in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 2022, Cell Mol Neurobiol; 42:1049-1064. doi:10.1007/s1 0571-020-00994-0.
15. Chauhan AK, Chandra PS, Goyal N, Chowdhury MR, Banerjee J, Tripathi M, et al Weak Ligaments and Sloping Joints: A New Hypothesis for Development of Congenital Atlantoaxial Dislocation and Basilar Invagination. 2020, Neurospine; 17:843-856
16. Kumar S, Banerjee J, Tripathi M, Chandra PS, Dixit AB. IDH1-R132H-FAT1-ROS-HIF-1? Signaling Pathway Inhibits Glioblastoma Tumor Progression. 2020, Neurol India; 68:1059-1060. doi: 10.4103/0028-3886.279707
17. Dixit AB, Srivastava A, Sharma D, Tripathi M, Paul D, Lalwani S, Doddamani R, Sharma MC, Banerjee J, Chandra PS (2020). Integrated Genome-Wide DNA Methylation and RNAseq Analysis of Hippocampal Specimens Identifies Potential Candidate Genes and Aberrant Signalling Pathways in Patients with Hippocampal Sclerosis. Neurology India; 68:307-313. doi: 10.4103/0028-3886.280649.
18. Yadav N, Banerjee J, Tripathi M, Chandra PS, Dixit AB (2020). Association of Genetic Polymorphisms in Tumor Necrosis Factor-Alpha Gene with the Risk of Intracerebral Hemorrhage in North Indian Population. Neurology India; 68:84-85. doi: 10.4103/0028-3886.279683
19. Vaid A, Patil C, Sanghariyat A, Rane R, Visani A, Mukherjee S, Joseph A, Ranjan M, Augustine S, Sooraj KP, Rathore V, Nema SK, Agraj A, Garg G, Sharma A, Sharma M, Pansare K, Krishna CM, Banerjee J, Chandra S (2020). Emerging Advanced Technologies Developed by IPR for Bio Medical Applications ?A Review. Neurology India; 68:26-34. doi: 10.4103/0028-3886.279707
20. Kumar K, Banerjee J, Tripathi M, Chandra PS, Dixit AB (2020). Epigenetic Regulation of mTOR Pathway in Malformations of Cortical Development. Neurology India; 67:1472-1473. doi: 10.4103/0028-3886.273613.
21. Bindra A, Kaushal A, Prabhakar H, Chaturvedi A, Chandra PS, Tripathi M, Subbiah V, Sathianathan S, Banerjee J, Prakash C (2019). Neuroprotective role of dexmedetomidine in epilepsy surgery: A preliminary study. Neurology India; 67:163-168. doi: 10.4103/0028-3886.253616.
22. Dixit AB, Sharma D, Tripathi M, Srivastava A, Paul D, Prakash D, Sarkar C, Kumar K, Banerjee J, Chandra PS (2018). Genome-wide DNA Methylation and RNAseq Analyses Identify Aberrant Signalling Pathways in Focal Cortical Dysplasia (FCD) Type II. Scientific Reports (Nature), 8:17976. doi: 10.1038/s41598-018-35892-5
BanerjeeJ , Chandra PS (2018). Altered transforming growth factor beta/SMAD3 signalling in patients with hippocampal sclerosis. Epilepsy Research, 146:144-150. doi: 10.1016/j.eplepsyres.2018.08.004
24. Srivastava A, Dixit AB, Paul D, Tripathi M, Sarkar C, Chandra PS, Banerjee J (2017). Comparative analysis of cytokine/chemokine regulatory networks in patients with hippocampal sclerosis (HS) and focal cortical dysplasia (FCD). Scientific Reports (Nature), 7:15904. doi: 10.1038/s41598-017-16041-w.
25. Banerjee J, Dixit AB, Srivastava A, Ramanujam B, Kakkar A, Sarkar C, Tripathi M & Chandra PS (2017). Altered glutamatergic tone reveals two distinct resting state networks at the cellular level in hippocampal sclerosis. Scientific Reports (Nature), 7:319. doi: 10.1038/s41598-017-00358-7.
26. Dixit AB, Sharma D, Srivasatava A, Banerjee J, Tripathi M, Prakash D, Chandra PS (2017). Upregulation of BCRP and MVP in Drug-resistant epilepsy. Seizure-European Journal of Epilepsy, 47:9-12. doi: 10.1016/j.seizure.2017.02.014
27. Dixit AB, Banerjee J, Chandra PS, Tripathi M. (2017). Advances in Epilepsy Research in India. Neurology India, 65(Supplement): S83-S92. doi: 10.4103/neuroindia.NI_1070_16
28. Dixit AB, Banerjee J, Tripathi M, Sarkar C, & Chandra PS. (2017) Synaptic roles of Cyclin dependent Kinase 5 and its implications in epilepsy. Indian Journal of Medical Research, 145:179-188. doi: 10.4103/ijmr.IJMR_1249_14.
29. Dixit AB, Banerjee J, Srivastava A, Tripathi M, Sarkar C, Kakkar A, Jain M, Sarat Chandra P (2016). RNA-Seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS. Genomics. 107, 178–188. doi: 10.1016/j.ygeno.2016.04.001
30. Chandra SP, Kurwale NS, Chibber SS, ,Banerjee J, Dwivedi R, Garg A, Bal C, Tripathi M, Sarkar C, Tripathi M. (2016) Endoscopic-Assisted (Through a Mini Craniotomy) Corpus Callosotomy Combined With Anterior, Hippocampal, and Posterior Commissurotomy in Lennox-Gastaut Syndrome: A Pilot Study to Establish Its Safety and Efficacy. Neurosurgery. 78, 743-51. doi: 10.1227/NEU.0000000000001060
31. Dixit AB, Tripathi M, Chandra PS & Banerjee J. (2016) Molecular Biomarkers in Drug-Resistant Epilepsy: Facts & Possibilities. International Journal of Surgery<>/b>, 36, 483-491. doi: 10.1016/j.ijsu.2015.08.029
32. Dixit AB, Banerjee J, Ansari A, Tripathi M, & Chandra PS. (2016) Mutations in GABRG2 receptor gene are not a major factor in the pathogenesis of mesial temporal Lobe Epilepsy in Indian population. Annals of Indian Academy of Neurology. 19, 236-241. doi: 10.4103/0972-2327.182304
33. Srivastava A, Dixit AB, Banerjee J, Tripathi M, Sarat Chandra P. (2015) Role of inflammation and its miRNA-based regulation in epilepsy: Implications for therapy. Clin Chim Acta. 452: 1-9. doi: 10.1016/j.cca.2015.10.023
34. Banerjee J, Dixit AB, Tripathi M, Sarkar C, Gupta YK & Chandra PS. (2015) Enhanced endogenous activation of NMDA receptors in pyramidal neurons of hippocampal tissues from patients with mesial temporal lobe epilepsy: a mechanism of hyper excitation. Epilepsy Research, 117: 11-16. doi: 10.1016/j.eplepsyres.2015.08.007
35. Dixit AB, Banerjee J, Tripathi M, & Chandra PS. (2015) Pre-surgical epileptogenic network analysis: A way to enhance epilepsy surgery outcome. Neurology India, 63:743-750. doi: 10.4103/0028-3886.166546
36. Banerjee J, Chandra PS, Kurwale N, & Tripathi M (2014) Epileptogenic networks and drug-resistant epilepsy: Present and future perspectives of epilepsy research- Utility for the epileptologist and the epilepsy surgeon. Annals of Indian Academy of Neurology, 17: 134-140. doi: 10.4103/0972-2327.128688
37. Banerjee J, Alkondon M, Albuquerque EX & Periera EFR. (2013) Contribution of CA3 and CA1 pyramidal neurons to the tonic ?7 nAChR-dependent glutamatergic input to CA1 pyramidal neurons. Neuroscience Letters, 554: 167-171. doi: 10.1016/j.neulet.2013.08.025
38. Banerjee J, Tripathi M and Chandra PS (2013) Understanding Complexities of Synaptic Transmission in Medically Intractable Seizures:A Paradigm of Epilepsy Research. Indian Journal of Neurosurgery, 2, 71-76. doi: 10.4103/2277-9167.110229
39. Banerjee J, Alkondon M, & Albuquerque EX. (2012) Kynurenic acid inhibits glutamatergic transmission to CA1 pyramidal neurons via ?7 nAChR-dependent and -independent mechanisms. Biochemical Pharmacology, 84:1078-1087. doi: 10.1016/j.bcp.2012.07.030
40. Banerjee J, Alkondon M, Periera EFR, & Albuquerque EX. (2012) Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid. Journal of Pharmacology and Experimental Therapeutics, 341: 500-509. doi: 10.1124/jpet.111.189860
41. Manna S*, Banerjee J*, & Ghosh S. (2007) Breathing of voltage dependent anion channel as revealed by the fractal property of its gating. Physica A, 386: 573-580. (* Both the authors contributed equally). doi: 10.1016/j.physa.2007.06.049.
42. Banerjee J, Singh J, Joshi MC, Ghosh S, & Banerjee N. (2006) The cytotoxic fimbrial structural subunit of Xenorhabdus nematophila is a pore-forming toxin. Journal of Bacteriology, 88: 7957-7962. doi: 10.1128/JB.00787-06
43. Banerjee J & Ghosh S. (2006) Phosphorylation of rat brain mitochondrial voltage dependent anion channel as a potential tool to control leakage of cytochrome c. Journal of Neurochemistry, 98: 670- 676. doi: 10.1111/j.1471-4159.2006.03853.x
44. Banerjee J, Verma MK, Manna S, & Ghosh S. (2006) Self-organised criticality and 1/f noise in single-channel current of voltage-dependent anion channel. Europhysics letters 73: 457-463. doi: 10.1209/epl/i2005-10418-2.
45. Verma MK, Manna S, Banerjee J, & Ghosh S. (2006) Universal scaling laws for large events in driven non-equilibrium systems. Europhysics letters, 76:1050-1056. doi: 10.1209/epl/i2006-10413-1
46. Banerjee J & Ghosh S. (2005) Investigating interaction of ligands with voltage dependent anion channel through noise analyses. Archives of Biochemistry and Biophysics, 435: 369-371. doi: 10.1016/j.abb.2004.12.019.
47. Banerjee J & Ghosh S. (2004) Bax increases the pore size of rat brain mitochondrial VDAC in the presence of tBid. Biochemical and Biophysical Research Communications, 323:310-314. doi: 10.1016/j.bbrc.2004.08.094
48. Banerjee J & Ghosh S. (2004) Interaction of mitochondrial Voltage-Dependent Anion Channel from Rat Brain with Plasminogen Protein leads to Partial Closure of the Channel. Biochimica et Biophysica Acta (BBA)-Biomembrane, 1663: 6-8. doi: 10.1016/j.bbamem.2004.02.005
Book Chapters:
49. Dheer A, Dixit AB, Tripathi M, Chandra PS, Banerjee J. Glia in epilepsy: an overview. In: Patro I, Seth P, Patro N, Tandon, PN (Eds) The Biology of Glial Cells: Recent Advances. Springer Singapore; 2022: pp 323–351. https://doi.org/10.1007/978-981-16-8313-8_12
50. Dey S, Dixit AB, Tripathi M, Chandra PS, Banerjee J. Cellular electrophysiological methods to decipher the altered synaptic transmission associated with drug-resistant epilepsy. In: Divya Vohora (Eds). Neuromethods, Vol. 167, Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy. Springer Nature; 2021: pp 55-76. doi: 10.1007/978-1-0716-1254-5_4
51. Dixit AB, Banerjee J. Epileptogenesis. In: Mukherjee A, Tripathi M (Eds). IAN Textbook of Neurology, First Edition. New Delhi: Indian Academy of Neurology & The Health Sciences Publisher (Jaypee); 2018: pp 187-192. doi: 10.5005/jp/books/18071_26
52. Ghosh S, Bhattacharjee A, Banerjee J, Manna S, Bhatraju NK, Verma MK, & Das MK. Electrical Noise in Cells, Membranes and Neurons. In: Dana SK, Roy PK, & Kurths J. (Eds.) Understanding Complex Systems: From Heart to Brain. Springer Berlin / Heidelberg, 2009: pp 255-267. doi: 10.1007/978-1-4020-9143-8_16.
Abstracts Published in Indexed Journals:
53. Dubey V, Dey S, Dixit AB, Tripathi M, Chandra PS, Banerjee J. Expression of glutamate receptor subunits in the hippocampus, anterior temporal lobe and neocortex of pilocarpine model of temporal lobe epilepsy. 34th International Epilepsy Congress, 28 August - 1 September 2021. (Published in Epilepsia 2021; 62 suppl:99).
54. Aggarwal Y, Vaid A, Doddamani R, Tripathi M, Chandra PS, Visani A, Joseph A, Banerjee J. Effectiveness of cold atmospheric plasma jet on the thickness of tumor samples obtained from patients with glioma. 34th International Epilepsy Congress (Virtual). 28 August- 1September 2021 (Published in Epilepsia 2021; 62 suppl:94).
55. Sharma D, Dixit A, Tripathi M, Doddamani R, Sharma MC, Lalwani S, Chandra PS, Banerjee J. GABAA Receptor subunit configuration alteration & its correlation with age of epilepsy onset. 34th International Epilepsy Congress (Virtual). 28 August- 1September 2021 (Published in Epilepsia 2021; 62 suppl:91).
56. Dey S, Dixit A, Tripathi M, Doddamani R, Chandra PS, Banerjee J. Modulation of kynurenine pathway in the hippocampus of patients with hippocampal sclerosis: A possible cause of hyperexcitability. 34th International Epilepsy Congress (Virtual). 28 August- 1September 2021. (Published in Epilepsia 2021; 62 suppl:89).
57. Dey S, Dixit A, Tripathi M, Chandra PS, Banerjee J. Role of pyridoxal phosphate in modulation of Endogenous kynurenic acid synthesis associated with hippocampal sclerosis. 20th joint conference of Indian Epilepsy society and Indian Epilepsy Association, ECON 2019, New Delhi, 8-10th March, 2019. (Published in International Journal of Epilepsy 2018; 05(02): S16). (Published in Epilepsia 2021; 62 suppl:89).
58. Srivastava A, Dixit A, Dodamanni R, Banerjee J, Tripathi M, Sharma MC, Lalwani S, Fozia S, Chandra PS. Altered Expression of Histone Deacetylases in Patients with Hippocampal Sclerosis. 21st Joint Annual Conference of Indian Epilepsy Association and Indian Epilepsy Society, ECON 2020, Ahmedabad. 17-19th Jan, 2020. (Published in International Journal of Epilepsy 2018; 05(02): S2-S3).
56. Dey S, Dixit A, Tripathi M, Doddamani R, Chandra PS, Banerjee J. Modulation of kynurenine pathway in the hippocampus of patients with hippocampal sclerosis: A possible cause of hyperexcitability. 34th International Epilepsy Congress (Virtual). 28 August- 1September 2021. (Published in Epilepsia 2021; 62 suppl:89).
59. Paul D, Dixit A, Srivastava A, Tripathi M, Tandon V, Banerjee J, Chandra PS. Activation of Transforming growth factor beta (TGF?) Signalling in mesial temporal lobe epilepsy (MTLE) patients. (Published in Epilepsia. 2016; 57(Suppl. 2):151).
.
60. Sharma D, Shrivastava A, Banerjee Dixit A, Banerjee J, Tripathi M, Chandra PS. Gene expression analysis of drug transporters and biotransformation enzyme in patients with mesial temporal lobe epilepsy and focal cortical dysplasia: a comparative study. (Published in Epilepsia. 2016; 57(Suppl. 2):52).
61. Banerjee J, Ghosh S. Role of voltage dependent anion channel (VDAC), Bax and Bid in cell death: an electrophysiological study. 30th FEBS Congress & 9th IUBMB Conference, July 2-7, 2005 at Budapest, Hungary. (Published in FEBS Journal. 2005, 272, (s1), [N3-015P], 27-28).